Headache and Pain Research

Sleep Disorders in Headache Patients: Hye Jeong Lee, Hee-Jin Im, Soo-Jin Cho, Min Kyung Chu; Korean J Headache. 2023;24(1):1-10. Published online June 30, 2023

Abstract PDF: Headache disorders and sleep problems are common conditions with a high prevalence in the general population, and impose a considerable socio-economic burden. They show a close association with headache disorders through various relationship. The prevalence of sleep problems is elevated in individuals with headache, especially for migraine. In most headache disorders, sleep problems are accompanied by the deterioration of clinical characteristics of headache disorders. The sharing brain structures and neurotransmitters involved in the pathogenesis of headache disorders and sleep disorders may be an explanation for the close relationship between two disorders. In this article, we briefly review the relationship of headache disorders with sleep disorders including insomnia, sleep-related breathing disorders, central disorders of hypersomnolence, circadian rhythm sleep-wake disorders, parasomnias, and sleep related movement disorders.

Diagnosis and Exclusion of Dangerous Headache in Headache Clinic Patients: Jiyoung Kim, Kyoung Jin Hwang; Korean J Headache. 2023;24(1):11-16. Published online June 30, 2023

Abstract PDF: There are many different types of headaches, but they can be broadly classified as primary and secondary headaches. The Diagnosis of Headaches involves understanding the epidemiology of headaches, identifying the signs of secondary headaches, and applying the diagnostic criteria outlined in the International Classification of Headache Disorders. Clinicians should have a clear understanding of SNNOOP10 to indicate secondary headache. Furthermore, the evaluation of patients who present with a thunderclap headache should be conducted with great care and detail.

Zavegepant: Intranasal Drug for Acute Migraine Treatment: Jong-Geun Seo; Korean J Headache. 2023;24(1):17-19. Published online June 30, 2023

Abstract PDF: Calcitonin gene-related peptide (CGRP) is probably the most potent vasodilator in cerebral circulation. The new CGRP-targeted therapy for the treatment of acute treatment are now available for clinical practice. This review article summarized efficacy and safety of zavegepant, which is the first intranasal small molecule CGRP receptor antagonist for acute migraine treatment.

Paradoxical Postural Headache in Spontaneous Intracranial Hypotension with Infratentorial Superficial Siderosis: Dae Woong Bae, Min Seung Kim, Soo-Jin Cho; Korean J Headache. 2023;24(1):20-23. Published online June 30, 2023

Abstract PDF: Spontaneous intracranial hypotension is characterized by orthostatic headache caused by cerebrospinal fluid (CSF) leakage. However, clinical presentation of SIH is variable, and normal or high intracranial pressure in CSF study is not uncommon. Infratentorial superficial siderosis (ISS) shares similar pathomechanism with SIH, as developed after chronic CSF leakage, whilst several years of latency after SIH onset. Here, we report a 47-year-old male patient who had experienced prominent orthostatic headache twenty years before, and presented reverse-orthostatic headache in this time, accompanying with radiological features of SIH and ISS in brain magnetic resonance imaging (MRI). CSF leakage was confirmed by spinal MRI and MR myelography, and his headache was aggravated after epidural blood patch.

First Report of a Korean Family with Familial Hemiplegic Migraine: Keun Lee, Seungyon Koh, Joo-Yeon Lee, Tae-Joon Kim; Korean J Headache. 2023;24(1):24-27. Published online June 30, 2023

Abstract PDF: We report a case of a Korean family with familial hemiplegic migraine type 2 (FHM2) carrying a heterozygous c.901G>A (p.G301R) mutation in the ATP1A2 gene. FHM is a subtype of migraine with a family history characterized by reversible hemiparesis and cortical symptoms that can last for hours to days. In Korea, there was only one case of sporadic hemiplegic migraine with ATP1A2 mutation, and no FHM2 family case was reported. The G301R mutation in ATP1A2 is a known pathogenic variant, previously reported in two Italian families. Our patient experienced repeated hemiplegic migraine with prolonged aura attacks with altered states of consciousness, and a clear pattern of autosomal dominance was observed in the family history. The patient, like typical FHM, has fully recovered within days. We report the first case of FHM2 Korean families with this mutation and highlight the importance of genetic testing for individuals with hemiplegic migraine.

Three Cases of Secondary Trigeminal Neuralgia Caused by Maxillary Sinus Cyst: Eungue Lee, Wonseok Jeon, Joongwon Park, Junho Choi, Jong-Hee Sohn, Ho Jun Lee, Sang-Hwa Lee; Korean J Headache. 2023;24(1):28-31. Published online June 30, 2023

Abstract PDF: Trigeminal neuralgia is a neuropathic pain disorder characterized by elicited paroxysms of stabbing pain in a specific region. Trigeminal neuralgia is classified into three types: classical, secondary, and idiopathic. The classic type, which is the most common, is caused by vascular compression of the trigeminal nerve root. Carbamazepine and oxcarbazepine are the first-line treatment choice for trigeminal neuralgia and offer meaningful pain control in almost 90% of patients. However, if there is no response to medical treatment, secondary trigeminal neuralgia should be considered. Secondary trigeminal neuralgia is attributed to an identifiable neurologic disease. Additionally, there are various secondary causes such as skull base fractures and paranasal sinus lesion. Two cases of secondary trigeminal neuralgia caused by maxillary sinus cyst were previously reported in South Korea. We experienced 3 cases of secondary trigeminal neuralgia induced by maxillary sinus cyst, which exhibited different clinical and radiological findings compared to the previous cases.

Previous issues