- 재진방문을 하지 않은 두통 환자의 원인 및 경과에 대한 후향적 분석
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Hyun-Jung Park, Ji-young Shim, Sun-hee Whang, Suk-Hee Kim, Jong-Ha Park, Soon-Tae Lee, Kon Chu, Man-ho Kim
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Korean J Headache. 2006;7(1):37-40. Published online June 30, 2006
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 Abstract
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- Background
The lost to follow-up is frequent among the patients w ith headache, but the extent or the reasons is unknown. To determine the frequency and the reason for the loss to follow-up, and to further evaluate the clinical course of headache w ithout m edication. Objects and M ethod s: Consecutive patients w ith headache visited the headache clinic in SNU H ospital w ere retros-pectively analyzed. Lost to the follow-up (LF) is determined w ho didn't m ake a re-visit following the prescription. Demographic characteristics, headache subtypes, and the reasons for the w ithdraw al w ere recorded by m edical record or telephone survey.
Results
1,090 patients w ith LF w ere evaluated (61.4% ). Sex ratio w as not different between LF group and follow-up group (men 24.0% , women 76.0% for LF). A ge distribution shows two folds higher in 20s and 30s when compared to follow-up group (5.6% 20s, 12.1% 30s for LF; 3.1% 20s, 6.4% 30s for follow-up). M igraine w as 17.6 times higher than the patients w ith tension type headache. The reasons for the LF were, ① improvem ent 35.8%, ② adverse event 12.0%, ③ no improvem ent 17.7% , ④ visit another hospital 5.0% , ⑤ etc 1.3% . Further analysis with the patients w ithout medications showed that ① headache aggravated 6.4% , ② stationary 45.4%, ③ improvement 23.3%, ④ unknown 24.9%.
Conclusions
Improvement is the m ost common reason for the LF. The outcom e w ithout m edication w as variable, suggesting it m ust be considered at a clinical research analysis. Korean Journal of Headache 7(1):37-40, 2006
- 한국인 편두통 환자와 미토콘드리아 DNA 11,084 유전자 다형성의 연관성
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Byung-Kun Kim, Hee-Joon Bae, Ja-Seong Koo, Oh-Hyun Kwon, Man-Ho Kim
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Korean J Headache. 2002;3(2):111-115. Published online December 31, 2002
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Abstract
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- Background
The genetic and molecular basis of migraine is still unknown. Clinical similarities bet- ween migraine and mitochondrial encephalomyopathies and the bias toward maternal transmission in family studies suggest that mitochondrial DNA(mtDNA) may play a role in migraine pathogenesis. An A-11,084-G substitution at mtDNA, has been reported in 25% of Japanese migraineurs. In contrast, in Danish individuals, this A-to-G mutation at mtDNA 11,084 was detected neither in persons with mig- raine nor in persons who had never had migraine. The aim of the present study was to investigate the frequency of this mutation in Korean migraineurs. Methods: One hundred migraineurs were studied after obtaining informed consent. A diagnosis of migraine was made on the basis of the International Headache Society criteria. DNA was purified from whole blood using DNA purification kit. For the analysis of mitochondrial nucleotide A-11,084-G substi- tution, mtDNA(bases 10,835 to 11,236) was amplified by polymerase chain reaction(PCR) using primers described previously. An A-11,084-G substitution generates BsmI restriction site. BsmI site containing PCR product(13,031～13,610 bases) was also amplified for positive-control. The amplified products were digested with 1 unit of BsmI, and were sized on a 1% TAE agarose gel with 100-bp DNA ladder marker. Results: None of the PCR products were cleaved by BsmI, whereas the positive controls were all digested by BsmI. We failed to detect the mtDNA A-11084-G substitution in our Korean patients with migraine. Conclusions: Mitochondrial DNA A to G polymorphism at 11,084 is not a risk factor for Korean mig- raineurs. This mutation may be rare in non-Japanese populations, which suggests ethnic difference in SNP genotype. Korean Journal of Headache 3(2):111-115, 2002
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KHS
