- 두통질환에서 보툴리눔 독소의 활용
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Man-Wook Seo
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Korean J Headache. 2005;6(1):54-69. Published online June 30, 2005
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 Abstract
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- Botulinum toxin, the most potent biological toxin known to man, was first isolated in 1897. For 2 deca- des, botulinum toxin A has been used for treating various disorders associated with muscular hypertrophy. Current research efforts focus on new areas of application for botulinum toxin A in specific pain therapy, particularly in headache. Clinical data and experience to date have demonstrated that BTX-A is an effec- tive and well-tolerated therapy for various headache disorders. Its long-term action lasting several months obviates the need to remember to take medication several times a day. Although inhibition of neuromus- cular activity may alleviate a portion of the pain associated with headache disorders, it does not fully explain the pain-relief mechanisms mediated by BTX-A. A reduction in afferent sensory activity coming from pericranial and cervical muscles, and inhibition of peripheral and central trigeminal sensitization, may be the potential mechanisms by which BTX-A exerts its therapeutic effect in various headache disor- ders. Further investigations will define the accurate pathophysiologic mechanisms of BTX-A in the head- ache management. Korean Journal of Headache 6(1):54-69, 2005
- 한국 대학생의 스포츠-연관성 두통의 유병률
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Man-Wook Seo, Sun Young Oh
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Korean J Headache. 2002;3(2):93-98. Published online December 31, 2002
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Abstract
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- Background
Previous studies suggested sports as a potent trigger of headaches. Compared with other headache syndromes, sports-related headaches(SRH) have attracted little academic interest. Therefore the precise epidemiology and characteristics of SRH remain uncertain. Methods: To investigate the characteristic features of SRH, we used a self-designed questionnaire, which was completed by 500 students of Jeonbuk National University in Korea. The subdivision of SRH was done based on clinical patterns. Results: Mean age of male-student respondents was 23.5±2.5 year old and that of female-student res- pondents was 21.6±1.5 year old. The prevalence of SRH among university students was 29.6%(148 of 500). The prevalence of SRH in male-students was slightly higher than that of female-students(30.3%, and 29.2%, respectively). The most common subtype of SRH, effort/ exertion headache, was slightly more prevalent in female students than in male students(94.4% and 92.2%, respectively). However, the prevalence of effort/exertion migraine in male students was slightly higher than that in female students (5.2% and 4.3%, respectively). Meanwhile, post-traumatic headache was found only in one male-student. A variety of sports and exercise were described as initiating SRH, sprinting being the most common. Whereas basketball and football predominantly initiated headache in male-students, sprinting and long distance running frequently caused headache in female-students. Precipitating factors were varied, the most common being cardiopulmonary overloading which accounted for 113(76%) of the SRH cases. Other precipitating factors were trauma, dehydration, heat, high altitude, hypoglycemia, and tiredness. Conclusions: This study demonstrated that sports- and exercise-related headaches are a common pro- blem among university students. Our results might be helpful to understand the characteristics of SRH and provide some basic information for future studies. Korean Journal of Headache 3(2):93-98, 2002
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