- 고혈압을 동반한 편두통 환자에서 칼슘통로 길항제 Lercanidipine의 두통빈도 감소 효과에 대한 전향적 공개 임상 연구
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Soon-Tae Lee, Jeung-Eun Park, Hyun-Jung Park, Ji-Young Sim, Sun-Hi Hwang, Jong-Ha Park, Lami Kang, Manho Kim
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Korean J Headache. 2005;6(2):149-153. Published online December 31, 2005
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 Abstract
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- Background
Anti-hypertensive medication is commonly used for the prophylaxis of migraine headache. Calcium channel blockers, verapamil, flunarizine, nimodipine or nifedipine have been tried as anti-migraine drug. Lercanidipine is developed as anti-hypertensive drug in Korea with high lipid solubility and longer duration of action. In this study, we attempted to test the efficacy of lercanidipine for the migraine with hypertension in an open labeled prospective study.
Patients and Methods: Consecutive 107 outpatients aged 20 to 70 years (mean, 61.4±9.9), were analyzed. Diagnosis of migraine was made according to the International Headache Society criteria, and the migraineurs were assigned to treatment with lercanidipine (10 mg/day) for 12 weeks. The efficacy variables included the changes in monthly headache frequency, Headache Management Self-Efficacy Scale (HMSE), and Headache Disability Inventory (HDI).
Results
Headache frequency showed 62.5% reduction for three months with responder rate of 73%. HMSE score showed an improvement whereas HDI scores remaind unchanged.
Conclusions
Lercanidipine is an effective prophylactic agent in migraine. A double-blind placebo-controlled clinical trial is warranted. Korean Journal of Headache 6(2):149-153, 2005
- 한국에서 편두통 예방 치료를 위한 평가 - 편두통에 의한 장애인식 캠페인 -
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Min-Kyung Chu, Sun Uck Kwon, Manho Kim, Byung-Kun Kim, Byung-Joo Kim, Yeong-In Kim, Yong-Jae Kim, Won-Joo Kim, Jae-Moon Kim, Hyun Sook Kim, Jin Kuk Do, Ki-Jong Park@
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Korean J Headache. 2005;6(2):121-128. Published online December 31, 2005
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Abstract
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- Background
Migraine is a common, disabling illness and imposes great burden on society. Migraine- related disability is often poorly communicated between patients and physicians. The prevalence, disability and medical service utilization behavior of migraine has not been evaluated sufficiently in Korea. The goal of this study is to determine the proportion of migraine among patients presented with headache in neurology clinic and to assess the level of headache related disability of patients.
Methods
This survey recruited patients who consulted to neurologists with a chief complaint of headache in 17 hospitals in Korea. Patients answered a self-administered questionnaire. The investigators independently responded another questionnaire about their patients' headache and assessed headache related disabilities after diagnostic interview. Patients suffering from headache ≥15 days per month were excluded.
Results
Among 570 patients (female 433 (76.0%), mean age 47.8±15.6) who responded adequately the questionnaire, 376 patients had migraine. Fifty-eight percent of the migraine patients were newly diagnosed as having migraine through this survey. However, 74.9% of migraineurs have taken pain-relieving drugs when headache developed; 12.3% of the migraineurs overused the medications. One hundred forty one (37.5%) migraineurs reported that they miss family, social and leisure activities because of headache. Thirty percents of migraineurs were on prophylactic medications and 14.4% of them have visited emergency room due to severe headache. The neurologists would recommend prophylactic medication in 64.3% of patients who were not on prophylaxis.
Conclusions
This study showed that migraine is the most common headache syndrome in the neu- rology clinics of Korea. Significant portion of the migraine patients have migraine-related disability. A majority of migraineurs exposed pain-relieving drugs without exact diagnosis and some of them overused them. Korean Journal of Headache 6(2):121-128, 2005
- 편두통 유전학의 최신지견
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Manho Kim
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Korean J Headache. 2003;4(1):7-13. Published online June 30, 2003
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Abstract
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- The genetics of migraine is a fascinating and moving research area. This review focuses on the di- fferent molecular genetic findings in migraine. Familial hemiplegic migraine(FHM) is a rare subtype of migraine with aura, which is inherited as an autosomal dominant. Half the cases of FHM are caused by point mutations in the CACNA1A gene. Other mutation types cause episodic ataxia 2(EA-2) or expan- sions of the CAG in SCA 6. The finding in an ion channel subunit defines migraine as a channelopathy (eg, epilepsy). Mutations in genes on the X chromosome, dopamine receptor genes, ACE gene, genes for nitric oxide synthase, serotonin receptors, MTHFR, and mitochondrial DNA have been investigated. The positive associations have not been reproduced in other studies and therefore they should be interpreted with care. It is to be hoped that in the next few years much more will be known about the molecular genetic mechanisms of migraine Korean Journal of Headache 4(1):7-13, 2003
- 일차성 두통의 유전학
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Manho Kim
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Korean J Headache. 2002;3(1):7-14. Published online June 30, 2002
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