- 감마나이프 방사선 수술로 치료된 증상성 삼차신경통
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Sang-Jun Lee, Young-Chul Choi, Soo-Joo Lee, Gun-Se Oh, Moon-Sun Park, Youngchai Ko
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Korean J Headache. 2011;12(2):101-104. Published online December 31, 2011
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 Abstract
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- A 62-year-old woman complained of facial pain. She was diagnosed with trigeminal neuralgia(TN) and had persistent symptoms despite adequate medication. After two years, she was admitted with acute stroke and magnetic resonance image revealed an enhanced solid mass in the left cerebellopontine angle(CPA). The CPA tumor was suggested as possible cause of intractable TN and the pain was relieved after Gamma-knife radiosurgery. We suggest that the comprehensive evaluation of etiology in patients with intractable TN should be recommended. And Gamma-knife radiosurgery can be an alternative treatment option.
- 한국인에서의 편두통과 도파민 D4수용체 유전자 다형태의 연관성
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Tae Jin Song, Ji Man Hong, Hyun-Suk Kim, Kyung-Yul Lee, Won-Joo Kim, Young-Chul Choi
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Korean J Headache. 2006;7(1):41-45. Published online June 30, 2006
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Abstract
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- Background
The dopam ine m etabolism is believed to play an important part in the pathophysiology of migraines. It was reported that the distribution of alleles for the dopamine D4 receptor gene (DRD4) in migraine w ithout aura patients is significantly different from those in control group. A polymorphism of the D RD4 m ight be related to genetic suscep- tibility of m igraine. The aim of this study w as to investigate the association of DRD4 exon III polymorphism between patient group w ith m igraine and control group.
Methods
This study compared 150 patients with m igraine (38 m ales, 112 females and m ean age 42.4±10.23) 100 healthy control subjects (25 males, 75 females and mean age 42.6±10.35) in order to determine the association between a polymorphism of the DRD4 exon III and m igraine. Using PCR techniques, the DRD4 polymorphism was denoted by 48-base-pair tandem repeat in exon III of the gene.
Results
There w as no significant difference between the healthy controls, m igraine without aura patients and m igraine with aura patients in age and sex distribution. Significant differences w ere noted in the genotype betw een m igraine without aura group and m igraine w ith aura group. Also significant differences w ere observed in allele frequencies compared m igraine w ithout patients w ith control group and m igraine w ith aura patients.
Conclusions
The DRD4 polymorphism appears to be involved in the genetic predisposition to m igraine w ithout aura. Migraine w ithout aura m ay have different pathophysiology from m igraine w ith aura in genetic field. Korean Journal of Headache 7(1):41-45, 2006
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