Abstract

Serotonin seems to have an important role in migraine pathogenesis and treatment. It is abundant in the brain, intestinal mucosa and platelats, which are important in migraine symptomatology. Recently developed specific serotonin(5-HT1) agonists, namely “triptans” showed the way how to effectively treat acute migraine in view of serotonin hypothesis. Further development of specific receptor angonists and antagonists may well define receptor function and elucidate the validity of the serotonin hypothesis. Korean Journal of Headache 1(1):15-17, 2000