Neurologic symptoms associated with murine typhus is relatively rare, almost accompanies with ma- culopapular rash, often fever, chilling and myalgia. We report a case of murine typhus, diagnosed by complement fixation test, exhibited initially only intractable headache without other cardinal features. This case suggest that neurologic manifestations such as isolated intractable headache and encephalopathy in murine typhus should be included in the differential diagnosis in epidemic areas. Korean Journal of Headache 2(1):61-73, 2001