Although controversial, Botulinum toxin type A(Botox) can be effectively used for migraine preven- tion. Injection of 25U Botox was reported to be effective for migraine prevention, but 75U without statistically significant effect. Furthermore, the way how to use Botox for each patients has not been evaluated. It may not be appropriate to inject Botox into scalp area far from migraine pain site. The author suggests for injecting Botox into and around migraine pain areas which vary from patient to patient. Korean Journal of Headache 4(1):60-62, 2003