Abstract

The objective of abortive treatment of migraine attack is to reduce the intensity and duration of pain with its attendant symptoms and to optimize the patient's ability to function normally. The efficacy of most abortive anti-migrainous drug is probably related to their inhibitory effects on neurogenic inflammation mediated through serotonergic control mechanisms. The migraine specific therapies are representative of new migraine abortive medications, which act as serotonin agonist- triptans and ergots. Treatment choices for acute migraine should be based on headache severity, migraine frequency, associated symptoms, and comorbidities. In this review, I described recent trends in acute migraine therapy with stress on evidence- based guideline for migraine headache in company with some remarks on the various triptans. Korean Journal of Headache 6(1):14-20, 2005