Abstract

Migraine and epilepsy are comorbid episodic central nervous system disorders that can have stereoty- ped symptoms with negative and positive phenomena. Controlled trials have demonstrated that anticon- vulsants appear to be both effective in reducing migraine frequency and reasonably well tolerated. There is noticeable variation among individual agents, but there are insufficient data to know whether this is due to chance or variation in true efficacy. Relatively few robust trials are available for agents other than sodium valproate/divalproex sodium. Three recently published and large trials of topiramate demonstrated reasonable efficacy. Anticonvulsants are a useful option for the preventive treatment of migraine. Korean Journal of Headache 6(1):47-53, 2005