Migraine is a primary neurovascular headache w hich affects approximately 12% of the adult population. It is also known migraine is a risk factor for ischemic stroke in young w omen w ith m igraine w ith aura. Recently, it was reported that some individuals that experience m igraine w ith and w ithout aura m ay be at an increased risk for subclinical lesions in certain areas of the brain. A subgroup of person with episodic m igraine m ay progress to chronic daily headache. These data have im plications for current concepts of m igraine as a progressive brain disease. So, the goals of treatm ent may also shift to preventing the accumulation of brain lesion and disease progression. Korean Journal of Headache 7(1):1-3, 2006