Abstract

Migraine is a common, disabling headache disorder and imposes a significant burden personally and socially. Recent advances in migraine treatment including new drugs for acute and preventive treatment make it possible for more effective migraine management. Newly introduced acute treatment drugs are second generation triptans, calcitonin gene- related related peptide receptor antagonist, 5-HT1D receptor inhibitor, and adenosine A1 receptor agonist. Second genera- tion triptans are almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan and zolmitriptan. New triptans offer more oral efficacy, a better adverse-event profile, a more rapid onset of action and a better response consistency. Newly introduced drugs for migraine preventive treatment are topiramate, zonisamide, levetiracetam, venlafaxine, botulinum toxin, lisinopril, candesartan, riboflavin, coenzyme Q10, magnesium, feverfew and petasites. Newly introduced migraine treatment drugs would help for more successful management of migraine.