Headache is a very common patient complaint but secondary causes for headache are unusual. But appropriate selection of patients with headache for neuroimaging and other various studies to look for secondary causes is very important. Most patients with intracranial pathology have clinical features that would raise a "red flag". Red flags act as screening tools to help in identifying those patients presenting with headache who would benefit from prompt diagnostic work up for serious intracranial pathology, and may increase the yield. This paper was written with the aim to determine the clinical features that identify those patients who should undergo further evaluation of serious intracranial pathology and provide useful tool for doctor in making diagnostic decisions in the management of patients of headache.