Migraine is a lifelong disabling recurring primary headache disorder. The ideal aims of acute therapy of migraine are rapid relief of pain and associating symptoms, no side effects, and no recurrence. Doctors should educate their patients to understand migraine before starting treatment. Furthermore, patients and doctors should discuss about their lifelong plan for migraine therapy. Many different medications have been used for acute therapy of migraine. But, only some drugs among them have sufficient evidence for use. I tried to review the strategies for acute treatment of migraine and introduce various medications for reducing migraine pain.