Abstract

In 1991 the Clinical Trials Subcommittee of the International Headache Society(IHS) published its first edition of the guidelines on controlled trials of drugs in migraine. The guidelines were developed because of a need to improve the quality of controlled clinical trials in migraine and to draw investigator’s attention to the problems inherent in drug trials in migraine. In this article, I will briefly review the guidelines of migraine, tension-type headache and cluster headache.