Headache is among the most common problems leading parents to seek medical attention for their children and adoles- cents and become increasing more frequent during adolescence. The majority of children and adolescents headache patients who are brought to a physician for evaluation will prove to have migraine. Although headaches in children and adolescents are generally benign, neuroimaging studies are frequently performed in clinical practice for the fear of missing a serious underlying disease. A thorough history, physical and comprehensive neurologic examination, and appropriate diagnostic testing will usually enable the clinician to distinguish a benign primary headache from a more serious disease with a secondary headache. To effectively treat sick episodic headache, the physician initially needs to identify potential triggers and outline an acute treatment strategy. The initial goal is to eliminate headache pain in two to four hours. The headache may last only one to two hours in children under the age of 12 years. In this case, a more moderate approach toward treatment can be taken. Not only were children shown to have significant disability due to migraine and recurrent headache, but also that successful acute and preventive treatment would resolve this disability. In dealing with headaches in children and adolescent, physician must consider both physical and psychological factors in determining the correct diagnosis. Here, I would like to mention about management of migraine, tension type headache in children and adolescents and comorbidity disorders in pediatric headache.