Abstract

The aim of this paper is to review mechanism of action of botulinum toxin A in pain relief. Botulinum toxin A used as treatment for various conditions related to excessive muscle spasm. However, desirable effect of botulinum toxin for pain has been detected in a way to treat disease with myogenic condition and now it has been tried for management of myofascial pain, low back pain and various types of headaches, including migraine. Recent studies suggested possibility of botulinum toxin in pain reduction through central pathway.