Abstract

Background
Migraine is a heterogeneous condition that results in a spectrum of disability among individuals. Under- standing factors associated with severe disability of migraine is an important step towards optimizing interventions. Objective: To describe factors associated with severe migraine-related disability. Methods: We assessed factors of severe disability in univariate and multivariate analyses. Multivariate analyses were adjusted for demographic factors, clinical features, headache severity and frequency. Results: One hundred and ninety migraine patients were enrolled in this study. In the unadjusted univariate analyses, severe pain was associated with severe disability compared to mild pain. Aggravation by routing physical activity, pho- tophobia, visual aura and eyeball pain were associated with severe disability of migraine. Taking less than 4 headache days per month as the reference, ≥15 headache days per month was associated with severe disability. In the adjusted multivariate analyses, aggravation by routine physical activity, visual aura and ≥15 headache days per month were associated with severe migraine-related disability. Conclusions: These results demonstrated that a significant proportion of migraine sufferers had severe disability and there are specific factors associated with severe disability.