Lemierre’s syndrome is a rare acute oropharyngeal infectious condition characterized by clinical features such as headache, neck pain, fever and chilling sense and radiologic evidence of internal jugular vein thrombosis. Although widespread use of antibiotics has led to a markedly improved the incidence and prognosis of this syndrome, Lemierre’s syndrome could be associated with significant morbidity and fatality. Moreover, no specific clinical features in the early stage of Lemierre’s syndrome may result in the delay of diagnosis. We report a 53-year-old male of Lemierre’s syndrome with sustained vascular headache and neck pain.