Spontaneous intracranial hypotension (SIH) is important cause of daily persistent headache and trivial traumatic events precede the onset of symptoms in about one third of patients. One patient presented with spinal cerebral fluid leakage manifesting as disabling headache after cycling with backpack. We discuss that wearing heavy backpack for a long time can affect musculoskeletal and soft tissue injury in the spine, then this event can result in SIH.