Volume 27(2); June 2026  
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Dear Colleagues,

We are pleased to present the second issue of the year, featuring four review articles (multimodal neuroimaging in RCVS, arterial dissection, and CVT; medication overuse and underuse in headache medicine; migraine in pilots; and trigeminal neuralgia), a guideline for cluster headache, and four original papers, including two articles on pediatric headache and dizziness.
Please find below the link to the table of contents and summaries of the esteemed articles.
Please enjoy, share and cite them.
Thank you for your support and assistance.

Office of Headache and Pain Research
Soo-Jin Cho, Editor-in-Chief; Soo-Kyoung Kim, Deputy Editor

Table of Contents Alert
Editorial

Looking into the Night: The Clinical Significance of Morning Headache
Soo-Kyoung Kim
DOI: http://doi.org/10.62087/hpr.2026.0024
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Review Articles

Temporal Evolution and Multimodal Neuroimaging in Reversible Cerebral Vasoconstriction Syndrome, Arterial Dissection, and Cerebral Venous Thrombosis
Young-Eun Gil
DOI: http://doi.org/10.62087/hpr.2026.0018
Cerebrovascular disorders are important secondary causes of headache, but diagnosis can be challenging because headache may be the earliest or only presenting symptom and initial neuroimaging findings are often normal or nonspecific. This review provides a systematic, imaging-focused discussion of three representative cerebrovascular headache disorders: reversible cerebral vasoconstriction syndrome (RCVS), cervical and intracranial artery dissection, and cerebral venous thrombosis (CVT)....
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Finding the Sweet Spot between Medication Overuse and Underuse in Headache Medicine
Hong-Kyun Park
DOI: http://doi.org/10.62087/hpr.2026.0012
Medication-overuse headache (MOH) is a well-recognized secondary headache caused by the frequent use of acute symptomatic medications, particularly among patients with underlying primary headache disorders such as migraine. Medication-underuse headache (MUH) is a recently proposed conceptual framework describing the suboptimal use of indicated treatments, including underuse, delayed administration, poor adherence, or premature discontinuation, all of which may contribute to headache...
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Migraine Management in Pilots: A Focused Narrative Review for the Treating Neurologist
Chan-Young Park, Dongwook Kang, Heejung Lim, Hae-Bong Jeong, Kwang-Yeol Park
DOI: http://doi.org/10.62087/hpr.2026.0019
Migraine, one of the leading global causes of disability, presents a complex challenge in aviation medicine. Headache is the fourth most common cause of in-flight pilot incapacitation, and cockpit-related exposures—including hypobaric hypoxia, low humidity, circadian disruption, and, in military aviation, sustained +Gz loading—may lower the migraine threshold. At the same time, aeromedical regulations restrict the medication options available to treating...
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Trigeminal Neuralgia: Pathophysiology, Clinical Features, and Therapeutic Management
Ekene Nnagha, Chidubem Adi, Daniel Akpan
DOI: http://doi.org/10.62087/hpr.2026.0005
Trigeminal neuralgia (TN) is a severe, disabling neuropathic facial pain disorder classified among cranial neuralgias within headache medicine. Despite well-established diagnostic criteria, TN remains frequently misdiagnosed, particularly in dental and primary care settings. This review provides a clinically focused overview of the epidemiology, pathophysiology, classification, diagnostic approach, and contemporary management of TN, with relevance to headache and pain research and...
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Original Articles

Guideline for the Treatment of Cluster Headache: A Clinical Practice Guideline from the Korean Headache Society
Byung-Su Kim, Pil-Wook Chung, Hong-Kyun Park, Mi Ji Lee, Jae Myun Chung, Kyung Min Kim, Jiyoung Kim, Heui-Soo Moon, Dae-Woong Bae, Jong-Hee Sohn, Tae-Jin Song, Wonwoo Lee, Soohyun Cho, Myoung-Jin Cha, Yun-Ju Choi, Miyoung Choi, The Clinical Practice Guideline Committee of the Korean Headache Society
DOI: http://doi.org/10.62087/hpr.2026.0011
Purpose: This clinical practice guideline (CPG) was developed by the Korean Headache Society (KHS) to provide evidence- based recommendations for the acute and preventive treatment of cluster headache (CH). Methods: The CPG Committee of the KHS identified key clinical questions regarding the acute and preventive treatment of CH through a systematic literature review. The Grading of Recommendations Assessment, Development and Evaluation...

The Impact of Limited Insurance Coverage on Long-Term Persistence with Anti-CGRP Monoclonal Antibody Therapy: A Multicenter Real-World Study in Korea
Mi-Kyoung Kang, Jong-Hee Sohn, Myoung-Jin Cha, Yoo Hwan Kim, Yooha Hong, Hee-Jin Im, Soo-Jin Cho
DOI: http://doi.org/10.62087/hpr.2026.0007
Purpose: Anti-calcitonin gene-related peptide monoclonal antibodies (anti-CGRP mAbs) are effective preventive therapies for migraine. However, their high cost limits long-term use. In Korea, coverage of anti-CGRP mAbs by the National Health Insurance Service (NHIS) is highly restricted. This study aimed to evaluate the association between NHIS coverage and treatment persistence in a real-world setting. Methods: This retrospective multicenter study included adult...
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Pediatric Headache: Children and Adolescents
Serum Triglyceride Levels in Pediatric Migraine and Tension-Type Headache: A Retrospective Study
Ki Taek Oh
DOI: http://doi.org/10.62087/hpr.2026.0016
Purpose: Migraine and tension-type headache (TTH) are the most common primary headache disorders in children. However, potential metabolic differences between these conditions remain incompletely understood. Methods: This retrospective study included pediatric patients diagnosed with migraine or TTH. Clinical characteristics and laboratory parameters were compared between the groups. Serum triglyceride (TG) levels were analyzed using multivariable linear regression adjusted for age and...

Diagnostic Spectrum of Orthostatic Intolerance and Otologic Diseases in Pediatric Patients with Primary Headache and Dizziness: A Single-Center Retrospective Study
Hey-Joon Son, Kon-Hee Lee
DOI: http://doi.org/10.62087/hpr.2026.0021
Purpose: Dizziness frequently coexists with headache in children and adolescents, but its diagnostic significance is often underrecognized. Orthostatic intolerance (OI) and otologic diseases are major causes of pediatric dizziness, yet distinguishing among these conditions remains clinically challenging. This study examined the diagnostic distribution of OI and otologic diseases in pediatric patients with primary headache-associated dizziness. Methods: We retrospectively reviewed 310 patients...
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Letters to the Editor

Comments on “Morning Headaches: An In-Depth Review of Causes, Associated Disorders, and Management Strategies”
Seong Taek Kim
DOI: http://doi.org/10.62087/hpr.2026.0014
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Sleep Bruxism as a Contributing Factor to Morning Headache: A Response to Recent Commentary
Yooha Hong, Hee-Jin Im
DOI: http://doi.org/10.62087/hpr.2026.0020
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Comments on “Brain Glymphatic and Lymphatic Systems in Migraine: Mechanistic Insights and Neuromodulation Perspectives with an Emphasis on Ultrasound-Based Approaches”
Soo-Jin Cho
DOI: http://doi.org/10.62087/hpr.2026.0015
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Headache and Pain Research (Headache Pain Res; pISSN: 3022-9057, eISSN: 3022-4764) publishes original articles, review articles, case report, letter to the editor, editorial, and perspective on all aspects of Headache and Pain Research. The main topics include migraine, cluster headache, tension-type headache, intracranial hypotension, intracranial hypertension, reversible cerebral vasoconstriction syndrome, other primary or secondary headache disorders, and issues related headache and pain such as dizziness, psychological, and cognitive problems. Headache and Pain Research is the official journal of Korean Headache Society, and aims to grow into an international journal and welcomes outstanding editorial board members and submissions from all over the world.

It is an Open Access journal, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. There is no article processing charge. Headache and Pain Research is published 3 times (the last day of February, June, and October) a year.
Editorial Office
Department of Neurology at Nowon Eulji Medical, Eulji University Hospital
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E-mail: office@e-hpr.org
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