Headache and Pain Research

Understanding the Connection between the Glymphatic System and Migraine: A Systematic Review: Myoung-Jin Cha, Kyung Wook Kang, Jung-won Shin, Hosung Kim, Jiyoung Kim; Headache Pain Res. 2024;25(2):86-95. Published online July 31, 2024; DOI: https://doi.org/10.62087/hpr.2024.0014

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The glymphatic system is a brain-wide perivascular pathway that functions similarly to the lymphatic system in the periphery of the body, playing a crucial role in removing waste from the brain. Although impaired glymphatic function has a well-known relationship with neurodegenerative diseases through abnormal protein accumulation, it is also associated with migraine. While still in its nascent phase, research on the glymphatic system in migraine patients is gradually increasing. This systematic literature review focuses on studies investigating the glymphatic system in migraineurs. Furthermore, it examines the methods used to evaluate the glymphatic system in these studies and their main findings.

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Diffusion Tensor Imaging-Based Glymphatic Dysfunction Assessments in Migraine Syndromes: Mechanisms and Diagnostic Implications
Emily Lai, Joshua Estin, Jiahao Zhou, Roger Sheffmaker, Manisha Koneru
Biomedicines.2025; 13(12): 2981. CrossRef

Migraine and Stroke: Myoung-Jin Cha, Ha Yeun Oh, Jiyoung Kim; Korean J Headache. 2023;24(2):50-55. Published online December 31, 2023

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Abstract PDF: The relationship between migraine and stroke is intricate and bidirectional. Migraine, a neurological disorder characterized by severe headaches and associated symptoms, exhibits some similarities in presentation with stroke. Conversely, stroke can at times mimic migraine symptoms. Migrainous infarction is directly associated with stroke. Specifically, migraine with aura has been linked to an increased risk of ischemic stroke. Migraine with aura and the frequency of headaches are considered risk factors for stroke. Moreover, migraine is associated with subclinical infarct-like brain lesions and white matter changes. Additionally, some genetic disorders predispose individuals to develop both migraine and stroke. In this review, we aim to investigate the relationship between migraine and stroke.

Diagnosis and Exclusion of Dangerous Headache in Headache Clinic Patients: Jiyoung Kim, Kyoung Jin Hwang; Korean J Headache. 2023;24(1):11-16. Published online June 30, 2023

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Abstract PDF: There are many different types of headaches, but they can be broadly classified as primary and secondary headaches. The Diagnosis of Headaches involves understanding the epidemiology of headaches, identifying the signs of secondary headaches, and applying the diagnostic criteria outlined in the International Classification of Headache Disorders. Clinicians should have a clear understanding of SNNOOP10 to indicate secondary headache. Furthermore, the evaluation of patients who present with a thunderclap headache should be conducted with great care and detail.

Update on Treatment of Giant Cell Arteritis: Mi-Kyoung Kang, Yoo Hwan Kim, Kyeong Min Son, Soo-Jin Cho , Jiyoung Kim, Jong-Hee Sohn, On behalf of the Hallym Headache Research Society; Published online December 31, 2022

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Abstract PDF: 거대세포동맥염의 최신 지견

Diagnostic Delay in Spontaneous Intracranial Hypotension: Jiyoung Kim, Younjin Park, Jong-Hee Sohn, Sang-Hwa Lee, Eun Kyung Khil, Hee Jin Im, Min Jun Song, Myoung-Jin Cha, Soo-Jin Cho; Published online June 30, 2022

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Abstract PDF: 자발두개내저압의 진단 지연

Status of Chronic Migraine Prophylactic Treatment in Clinical Practice: Jae Seob Yoon, Jiyoung Kim; Published online June 30, 2021

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Abstract PDF: 진료 현장에서 만성편두통의 예방약제 사용 현황

Thunderclap Headache Attributed to Spinal Subarachnoid Hemorrhage: Nae Ri Kim, Jiyoung Kim; Published online June 30, 2021

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Abstract PDF: 척수 거미막밑출혈에 기인한 벼락두통

Diagnosis and Treatment of Tension-type Headache: Myoung-Jin Cha, Jiyoung Kim, Ph.D.; Published online June 30, 2020

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Abstract PDF: 긴장형두통의 진단 및 치료

Does Insomnia Cause Migraines or Is It an Issue of Comorbidity?: Jiyoung Kim; Published online December 31, 2015

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Abstract PDF: 불면증은 편두통의 원인인가, 동반질환인가?

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