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Review Article
- Update on Cluster Headaches: From Genetic to Novel Therapeutic Approaches
- Myun Kim, Je Kook Yu, Yoo Hwan Kim
- Headache Pain Res. 2024;25(1):42-53. Published online April 22, 2024
- DOI: https://doi.org/10.62087/hpr.2024.0009
- 2,162 View
- 55 Download
- 4 Citations
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Abstract
PDF - Cluster headaches affect 0.1% of the population and are four times more common in males than in females. Patients with this condition present with severe unilateral head pain localized in the frontotemporal lobe, accompanied by ipsilateral lacrimation, conjunctival injection, nasal congestion, diaphoresis, miosis, and eyelid edema. Recently, the first genome-wide association study of cluster headaches was conducted with the goal of aggregating data for meta-analyses, identifying genetic risk variants, and gaining biological insights. Although little is known about the pathophysiology of cluster headaches, the trigeminovascular and trigeminal autonomic reflexes and hypothalamic pathways are involved. Among anti-calcitonin gene-related peptide monoclonal antibodies, galcanezumab has been reported to be effective in preventing episodic cluster headaches.
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Citations
Citations to this article as recorded by
- Exercise as an abortive treatment for cluster headaches: Insights from a large patient registry
Mi‐Kyoung Kang, Yooha Hong, Soo‐Jin Cho
Annals of Clinical and Translational Neurology.2025; 12(1): 149. CrossRef - Morning Headaches: An In-depth Review of Causes, Associated Disorders, and Management Strategies
Yooha Hong, Mi-Kyoung Kang, Min Seung Kim, Heejung Mo, Rebecca C. Cox, Hee-Jin Im
Headache and Pain Research.2025; 26(1): 66. CrossRef - Side Shift of Attacks in Cluster Headache: A Prospective Single-center Study
Michelle Sojung Youn, Jun Pyo Kim, Mi Ji Lee
Headache and Pain Research.2024; 25(2): 96. CrossRef - Reduction of neck pain severity in patients with medication-overuse headache
Yooha Hong, Hong-Kyun Park, Mi-Kyoung Kang, Sun-Young Oh, Jin-Ju Kang, Heui-Soo Moon, Tae-Jin Song, Mi Ji Lee, Min Kyung Chu, Soo-Jin Cho
The Journal of Headache and Pain.2024;[Epub] CrossRef
- Exercise as an abortive treatment for cluster headaches: Insights from a large patient registry
- Crowned Dens Syndrome Mimicking Meningitis
- Na Hee Kim, Myun Kim, Chaery Jeon, Yoo Hwan Kim
- Published online June 30, 2022
- 289 View
- 51 Download
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