Volume 26(3); October 2025  
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Dear Colleagues,

We are pleased to announce the publication of the third issue of Headache and Pain Research.
Please find below the link to the table of contents and summaries of the esteemed articles.
Please enjoy, share and cite them.
Thank you for your support and assistance.

Office of Headache and Pain Research
Soo-Jin Cho, Editor-in-Chief; Soo-Kyoung Kim, Deputy Editor

Table of Contents Alert
Editorial

Toward Precision Migraine Care: Genetics, Symptoms, and Big-Data-Driven Approaches
Soo-Jin Cho
DOI: http://doi.org/10.62087/hpr.2025.0017
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Review Articles

A Practical Approach to Headache in Moyamoya Disease
Mi-Yeon  Eun, Jin-Man Jung, Jay Chol Choi
DOI: http://doi.org/10.62087/hpr.2025.0011
Moyamoya disease (MMD) is a progressive steno-occlusive cerebrovascular disorder of the intracranial internal carotid arteries characterized by fragile collateral vessel formation. Although ischemic and hemorrhagic strokes are the most widely recognized manifestations of MMD, headaches are common, often disabling, and remain underacknowledged. Epidemiological studies report headache in 17%–85% of MMD patients, with particularly high rates among pediatric patients. Clinically, headache...
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Gepants for Migraine: An Update on Long-Term Outcomes and Safety Profiles
Soohyun Cho, Kimoon Chang
DOI: http://doi.org/10.62087/hpr.2025.0012
Calcitonin gene-related peptide receptor antagonists, also referred to as gepants, represent a transformative advancement in migraine pharmacotherapy, providing both acute and preventive treatment options without the vasoconstrictive limitations of triptans. Since their initial approval in 2019, gepants have gained widespread clinical adoption, necessitating comprehensive evaluation of their long-term safety and efficacy. This review synthesizes current evidence on four calcitonin gene-related...
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Headache as a Somatic Symptom in Pediatrics: Diagnosis and Integrated Management
Hye Eun Kwon
DOI: http://doi.org/10.62087/hpr.2025.0016
Somatization—the expression of psychological distress through physical symptoms—presents a frequent and complex challenge in pediatric practice. Headache and dizziness are among its most common manifestations. This review addresses the diagnostic challenge of determining whether these symptoms indicate a primary headache disorder or reflect somatic symptom presentations. The difficulty becomes particularly evident when conditions manifest in severe or persistent forms, such...
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Interictal Burden of Migraine: A Narrative Review
Soo-Kyoung Kim, Todd J. Schwedt
DOI: http://doi.org/10.62087/hpr.2025.0018
Migraine is a chronic neurological disorder associated with substantial disability and societal costs. Traditionally, research and clinical care have focused on the ictal phase, characterized by headache and accompanying symptoms. However, growing evidence suggests that a considerable portion of migraine-related disability occurs between attacks, known as the interictal burden (IIB). IIB encompasses a wide spectrum of cognitive, emotional, sensory, and...
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The Hidden Risks of Medication Underuse in Migraine Progression
Heui-Soo Moon, Pil-Wook Chung
DOI: http://doi.org/10.62087/hpr.2025.0019
Migraine is a progressive neurological disorder in which inadequate treatment can lead to chronification. For decades, clinical attention has centered on medication overuse headache (MOH) as the primary iatrogenic risk factor for this progression. However, medication underuse (MU) has emerged as a critical yet less established framework for understanding gaps in migraine care. This review reframes MU, which includes ineffective...
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Original Article

Trigeminal Autonomic Cephalalgias Following Unilateral Dorsolateral Medullary Infarction: A Case Series and Literature Review
Jae-Myung Kim, Hak-Loh Lee, You-Ri Kang, Joon-Tae Kim, Seung-Han Lee
DOI: http://doi.org/10.62087/hpr.2025.0013

Purpose: Secondary trigeminal autonomic cephalalgias (TACs) are typically associated with posterior fossa abnormalities, such as tumors and vascular malformations. However, TACs following brainstem infarctions are rarely reported. This study aimed to characterize the clinical and anatomical features of TACs after unilateral dorsolateral medullary infarction. Methods: We analyzed four patients with dorsolateral medullary infarction who developed secondary TACs, diagnosed using the International...
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Case Report

Isolated Dental and Lower-Facial Pain Mimicking Trigeminal Neuropathy: An Indirect Carotid-Cavernous Fistula
Byoungchul Choi, Chulho Kim, Sung-Hwan Kim, Jong-Hee Sohn
DOI: http://doi.org/10.62087/hpr.2025.0020
Carotid-cavernous fistula (CCF) is a pathological arteriovenous communication in which carotid arterial flow is diverted into the cavernous sinus. Clinical manifestations typically include ocular signs, cranial neuropathies, and headache. Neurologic deficits most commonly reflect involvement of cranial nerves III, IV, V1/V2, and VI within or along the cavernous sinus; in contrast, isolated trigeminal presentations are rare, and V3 involvement is...
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Correction

Erratum to “Premonitory Symptoms in Migraine: Implications for Disease Burden and Cognitive Impairment, with Some Promising Answers”
Utku Topbaş, Bahar Taşdelen, Nevra Öksüz Gürlen, Aynur Özge
DOI: http://doi.org/10.62087/hpr.2024.0031.e1
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Headache and Pain Research (Headache Pain Res; pISSN: 3022-9057, eISSN: 3022-4764) publishes original articles, review articles, case report, letter to the editor, editorial, and perspective on all aspects of Headache and Pain Research. The main topics include migraine, cluster headache, tension-type headache, intracranial hypotension, intracranial hypertension, reversible cerebral vasoconstriction syndrome, other primary or secondary headache disorders, and issues related headache and pain such as dizziness, psychological, and cognitive problems. Headache and Pain Research is the official journal of Korean Headache Society, and aims to grow into an international journal and welcomes outstanding editorial board members and submissions from all over the world.

It is an Open Access journal, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. There is no article processing charge. Headache and Pain Research is published 3 times (the last day of February, June, and October) a year.
Editorial Office
Department of Neurology at Nowon Eulji Medical, Eulji University Hospital
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E-mail: office@e-hpr.org
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