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Original Article
- Evidence-Based Recommendations on Pharmacologic Treatment for Migraine Prevention: A Clinical Practice Guideline from the Korean Headache Society
- Byung-Su Kim, Pil-Wook Chung, Jae Myun Chung, Kwang-Yeol Park, Heui-Soo Moon, Hong-Kyun Park, Dae-Woong Bae, Jong-Geun Seo, Jong-Hee Sohn, Tae-Jin Song, Seung-Han Lee, Kyungmi Oh, Mi Ji Lee, Myoung-Jin Cha, Yun-Ju Choi, Miyoung Choi
- Headache Pain Res. 2025;26(1):5-20. Published online January 16, 2025
- DOI: https://doi.org/10.62087/hpr.2024.0019
- 386 View
- 36 Download
- 2 Citations
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Abstract
PDF - Purpose: The aim of this clinical practice guideline (CPG) from the Korean Headache Society is to provide evidence-based recommendations on the pharmacologic treatment for migraine prevention in adult migraine patients.
Methods
The present CPG was developed based on the guideline adaptation methodology through a comprehensive systematic search for literature published between January 2012 and July 2020. The overall quality of the CPGs was assessed using the Korean version of the Appraisal of Guidelines for Research and Evaluation II tool. High-quality CPGs were adapted to make key recommendations in terms of strength (strong or weak) and direction (for or against).
Results
The authors selected nine available high-quality guidelines throughout the process of assessment of quality. Regarding oral migraine preventive medications, propranolol, metoprolol, flunarizine, sodium divalproex, and valproic acid are recommended to adult patients with episodic migraines based on high-quality evidence (“strong for”). Topiramate can be recommended for either episodic or chronic migraine (“strong for”). For migraine prevention using calcitonin gene-related peptide monoclonal antibodies, galcanezumab, fremanezumab, erenumab, and eptinezumab are recommended for adult patients with either episodic or chronic migraine on the basis of high-quality evidence (“strong for”). OnabotulinumtoxinA is recommended for adult patients with chronic migraine based on high-quality evidence (“strong for”). Last, frovatriptan, naratriptan, and zolmitriptan are recommended for short-term prevention in women with menstrual migraine (“strong for”).
Conclusion
In the present CPG, the authors provide specific, straightforward, and easy-to-implement evidence-based recommendations for pharmacologic migraine prevention. Nevertheless, these recommendations should be applied in real-world clinical practice based on optimal individualization. -
Citations
Citations to this article as recorded by
- One-Year Compliance After Calcitonin Gene-Related Peptide Monoclonal Antibody Therapy for Migraine Patients in a Real-World Setting: A Multicenter Cross-Sectional Study
Mi-kyoung Kang, Jong-Hee Sohn, Myoung-Jin Cha, Yoo Hwan Kim, Yooha Hong, Hee-Jin Im, Soo-Jin Cho
Journal of Clinical Medicine.2025; 14(3): 734. CrossRef - Beyond the Pain: Rethinking Migraine Care with the RELIEF PLAN Approach
Sanghyo Ryu
Headache and Pain Research.2025; 26(1): 1. CrossRef
- One-Year Compliance After Calcitonin Gene-Related Peptide Monoclonal Antibody Therapy for Migraine Patients in a Real-World Setting: A Multicenter Cross-Sectional Study
- Persistent Headache after Pulling Physical Activity as a First Manifestation of Vertebral Artery Dissection
- Byung-Su Kim, Hyun-Jeung Yu, Eun Hye Jeong, MunKyung Sunwoo, Min-Jae Sung, Dae Yoon Kim, Hyun Jin Kim, Jeongyeon Kim
- Published online December 31, 2022
- 245 View
- 29 Download
- Two Case Report of Melatonin Add-on Therapy for Cluster Headache
- Byung-Su Kim, Myoung-Jin Cha, Soo-Jin Cho
- Published online December 31, 2021
- 267 View
- 44 Download
- Diagnostic Delay of Cluster Headache in Korea
- Byung-Su Kim, Soo-Kyoung Kim, Pil-Wook Chung, Byung-Kun Kim, Mi Ji Lee, Min Kyung Chu, Jin-Young Ahn, Dae Woong Bae, Tae-Jin Song
- Published online June 30, 2020
- 492 View
- 154 Download
- Herpes Simplex Virus Encephalitis Complicated by Cerebral Venous Sinus Thrombosis Presenting with New-onset Headache
- Hee Jin Lee, Byung-Su Kim, Yun Kyung Park
- Published online December 31, 2018
- 277 View
- 39 Download
- Relapsed Stabbing Headache as the Presenting Manifestation of Aggravated Intracranial Hemangiopericytoma
- Young Ik Jung, Byung-Su Kim, Junghee Seo, Hee Jin Lee, Hyun-Jeung Yu, Eun Hye Jeong, MunKyung Sunwoo, Yun Kyung Park
- Published online December 31, 2018
- 263 View
- 34 Download
- Retropharyngeal Lymphadenitis Presenting with an Uncommon Headache Manifestation
- Byung-Su Kim, Mun Kyung Sunwoo, Eun Hye Jeong, Hyun-Jeung Yu, Dae Yoon Kim, Jeongyeon Kim
- Published online December 31, 2017
- 319 View
- 43 Download
- A Case of Superior Orbital Fissure Syndrome Attributed to Sinusitis Presenting Unilateral Throbbing Headache
- Byung-Su Kim, Byung-Kun Kim, Soo-Kyoung Kim, Jae-Moon Kim, Heui-Soo Moon, Kwang-Yeol Park, Jong-Hee Sohn, Tae-Jin Song, Min Kyung Chu, Myoung-Jin Cha, Soo-Jin Cho, J
- Published online December 31, 2017
- 480 View
- 111 Download
- The Frequency and Characteristics of Other Primary Headache Disorders in First-Visit Headache Patients in Korea: A Multicenter Study
- Myoung-Jin Cha, Byung-Kun Kim, Byung-Su Kim, Jong-Hee Sohn, Soo-Kyoung Kim, Heui-Soo Moon, Tae-Jin Song, Jae-Moon Kim, Jeong Wook Park, Min Kyung Chu, Kwang-Yeol Park
- Published online December 31, 2017
- 485 View
- 89 Download
- Natural Products in Migraine Prophylaxis
- Byung-Su Kim, M.S.
- Published online June 30, 2016
- 990 View
- 201 Download
- Upper Cervical Myelitis Presenting as Isolated Occipital Neuralgia
- Eun Hye Jeong, Hyun-soon Jang, Mun Kyung Sunwoo, Byung-Su Kim, Hyun-Jeung Yu, Sook Young Roh, Jeong Yeon Kim
- Published online December 31, 2015
- 507 View
- 56 Download
- Exercise: Trigger Factor of Migraine or Not ?
- Byung-Su Kim
- Published online December 31, 2015
- 609 View
- 117 Download
- Aggravation by Routine Physical Activity and Associated Factors in the Korean Migraine Population
- Byung-Su Kim, Min Kyung Chu, Byung-Kun Kim, Jae-Moon Kim
- Published online June 30, 2015
- 976 View
- 181 Download
- Immunotherapy-responsive Recurrent Painful Ophthalmoplegic Neuropathy
- Byung-Su Kim, Sook Young Roh, Hyun-Jeung Yu, Eun Hye Jeong, Mun Kyung Sunwoo, Hyun-soon Jang
- Published online December 31, 2014
- 636 View
- 62 Download
- Clinical Characteristics of Migraine Subjects with Nausea and Vomiting:An Analysis of Data from the Korean Headache Survey
- Byung-Su Kim, Chin-Sang Chung, Chung-Bin Lee, Min Kyung Chu
- Published online December 31, 2013
- 1,001 View
- 155 Download
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